An increased dose of MSG without the presence of food was most likely to cause a reaction. However, the researchers were unable to replicate the results when they repeated the test with the same of participants. This suggests that outside factors, such as food intake, may have caused the reactions.
In , a review of studies concluded that eating MSG with food had no significant influence on the occurrence of headaches. However, one study included in the review reported a significant link between the consumption of MSG and headaches in female participants. The authors concluded that, overall, the methods used could not produce reliable, consistent results and that more research is needed.
It is important to note that an organization that promotes the use of glutamate employs one of these authors. Researchers commonly administer MSG to mice to induce obesity. In the past decade, some people have wondered whether MSG intake is also linked to extra weight in humans.
One study from found that MSG was associated with an increase in weight in healthy Chinese adults. However, there have been conflicting results. People report various health issues that they associate with MSG. According to a Korean study from , the most common complaints were:. Severe and life-threatening symptoms are rare.
They resemble the symptoms of an allergic reaction and include:. Mild symptoms typically clear up without treatment.
A person with these symptoms may benefit from:. A doctor may recommend OTC or prescription medications to relieve these symptoms. Treatments include:. MSG eaten in normal amounts does not cause adverse effects in most people; however, if you are sensitive to MSG the only way to prevent symptoms is by cutting out foods that contain the additive.
Anyone with a sensitivity to MSG should check whether it is included on food labels. Remember to also check for the full name: monosodium glutamate. This activation leads to the release of nitric oxide, which then leads to the dilation or widening of blood vessels around the skull. Most people with an MSG-related headache describe a tightening or even burning head sensation.
In people with a history of migraines , MSG triggers a migraine—in this instance, people usually report a classic throbbing or pulsating headache. Foods that commonly contain added MSG are Chinese food in particular, soy sauce , canned vegetables, soups, and processed meats.
Though generally regarded as safe by the U. MSG-induced symptoms are typically not severe and subside on their own entirely within 72 hours. However, if your symptoms do not appear to resolve or continue worsening after 48 hours, speak to your healthcare provider, as it may be something more serious.
To help symptoms subside faster, drink only water, and a lot of it—at least half of your body weight in ounces. For example, if you weigh pounds, drink at least 75 ounces of water. Adequate hydration will help your kidneys to process MSG and flush it from your system. In addition, limit sodium intake until symptoms dissipate.
Sodium promotes water retention and will make it harder for your body to release the MSG through urination. If you suspect MSG is a headache or migraine trigger for you, avoiding it is probably your best bet. Unlike other food sensitivities, it is unlikely that you can build up a tolerance for MSG.
Keeping a diary of your headache symptoms and possible triggers can help you and your healthcare provider to pinpoint the causes of your headaches and develop the right treatment plan for you. Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. Monosodium glutamate 'allergy': menace or myth? Clin Exp Allergy. Obayashi Y, Nagamura Y. Does monosodium glutamate really cause headache? J Headache Pain.
The International Classification of Headache Disorders, 3rd edition beta version. Effect of systemic monosodium glutamate MSG on headache and pericranial muscle sensitivity. Questions and answers on monosodium glutamate MSG. Water, hydration, and health. Nutr Rev. However, researchers have found no definitive evidence of a link between MSG and these symptoms.
Researchers acknowledge, though, that a small percentage of people may have short-term reactions to MSG. Symptoms are usually mild and don't require treatment.
The only way to prevent a reaction is to avoid foods containing MSG. Katherine Zeratsky, R. There is a problem with information submitted for this request. Sign up for free, and stay up-to-date on research advancements, health tips and current health topics, like COVID, plus expert advice on managing your health. Error Email field is required.
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