Where is 1 alpha hydroxylase

This work was funded in part by a Medical Research Council project grant. Walters MR. Endocr Rev. N Engl J Med. Google Scholar. Vitamin D. San Diego : Academic Press; — J Bone Miner Res. J Am Soc Nephrol. Zehnder D , Hewison M. Mol Cell Endocrinol. Current Opin Nephrol Hyperten. Adams JS. Bell NH. Eur J Endocrinol. Trends Endocrinol Metab. Am J Med. J Clin Invest. J Clin Endocrinol Metab.

J Exp Med. Mol Endocrinol. Biochem Biophys Res Commun. Curr Opin Nephrol Hypertens. Am J Hum Gen. Kidney Int. Bikle DD. J Nut. J Biol Chem. Pillai S , Bikle DD. J Cell Physiol. Vandekerkhof PCM. Br J Dermatol. Efficacy and safety of topical calcitriol 1,dihydroxyvitamin D 3 for the treatment of psoriasis. J Am Acad Dermatol. Studies from our own group have focused on the distribution of 1alpha-OHase in both renal and extra-renal tissues.

Further immunohistochemical analyses have shown that the enzyme is widely distributed in extra-renal tissues, and this appears to be due to the same gene product as the kidney.

Collectively, these observations have raised important new questions concerning the role of 1alpha-OHase in vitamin D signalling at a local level. In lymph nodes and skin from these patients 1 alpha-hydroxylase expression was observed in cells positive for the surface antigen CD68 macrophages. The data presented here confirm the presence of protein for 1 alpha-hydroxylase in several extrarenal tissues, such as skin, placenta, and lymph nodes.

The function of this enzyme at novel extrarenal sites, such as adrenal medulla, brain, pancreas, and colon, remains to be determined. PaxDb i. PeptideAtlas More PeptideAtlas i. PRIDE i. ProteomicsDB: a multi-organism proteome resource More ProteomicsDB i.

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Human Protein Atlas More HPA i. BioGRID i. BindingDB database of measured binding affinities More BindingDB i. RNAct i. SMR i. Database of comparative protein structure models More ModBase i. Ensembl GeneTree More GeneTree i. InParanoid i. OMA i. Database of Orthologous Groups More OrthoDB i. Database for complete collections of gene phylogenies More PhylomeDB i. TreeFam database of animal gene trees More TreeFam i. Gene3D i. Integrated resource of protein families, domains and functional sites More InterPro i.

Pfam protein domain database More Pfam i. Protein Motif fingerprint database; a protein domain database More